Jonathan Friedman,
Assistant Professor.

Education

Harvard University. Ph.D. 1986 (Organic Chemistry).
Massachusetts Institute of Technology. Sc.B. 1981 (Chemistry).

Honors, Fellowships, etc.

June Coffin Childs Fund for Medical Research: 1986-1989
Postdoctoral Fellow, Yale University: 1986-1989

Research Interests

Organic Chemistry

Macromolecular X-ray crystallography is a technique that allows one to determine the three-dimensional structure of proteins and nucleic acids. Structure-based drug design is a process whereby one uses such experimentally determined three-dimensional protein structures to find new organic ligands that may bind to proteins and affect their biochemical activity. Our research involves both (1) the determination of protein structures for use in structure-based drug design and (2) the experimental measurement of intermoleular interactions to improve upon the currently available techniques for structure-based drug design.
For more detail look here.

Recent Publications

"Crystal structures of the large (Klenow) fragment of Escherichia coli DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate," L. S. Beese, J. M. Friedman, and T. A. Steitz, Biochemishy, in press (1993).

"Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor," L. A. Kohlstaedt, J. Wang, J. M. Friedman, P. A. Rice, and T. A. Steitz, Science, 256, 1783 (1992).

"Holding on and letting go: A new structure yields insight into the molecular basis for processivity during gene replication," Current Biology, 2, 296 (1992).

"Crystal structure at 3.5 Å Resolution of HIV-I Reverse Transcriptase Complexed with an Inhibitor," L. A. Kohlstaedt, J. Wang, J. M. Friedman, P. A. Rice, and T. A. Steitz, Science, 256, 1783-1790 (1992).

"The quest for free metaphosphate in solution: racemization at phosphorus in the transfer of the phospho group from aryl phosphate monoesters to tert-butyl alcohol in acetonitrile or in tert-butyl alcohol," J. M. Friedman, S. Freeman, and J. R. Knowles, J. Am. Chem. Soc. 110, 1268-1275 (1988).

"Co-crystal structure of an editing complex of Klenow fragment with DNA," P. S. Freemont, J. M. Friedman, L. S. Beese, M. R. Sanderson, and T. A. Steitz, Proc. Natl. Acad. Sci. USA 85, 8924-8928 (1988).

"Genetic and crystallographic identification of essential groups in the 3'-5' exonucleolytic site of DNA polymerase I," V. Derbyshire, P. S. Freemont, M. R. Sanderson, L. S. Beese, J. M. Friedman, C. M. Joyce, and T. A. Steitz, Science, 240, 199-201 (1988).

Contact Information

Email: friedman@kitten.chem.uh.edu
Office Location: 2?? Fleming (F)
Phone: (713) 743-2747 (office)
Fax: (713) 743-2709

USmail:

   Jonathan M. Friedman
   Department of Chemistry
   University of Houston
   Houston, TX 77204-5641
   USA

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