Kurt L. Krause
Associate Professor
Ph. D., Harvard University, 1986
M. D. Baylor Coll. Med., 1980


Office: HSC 466
Phone: (713) 743-8370
email: kkrause@uh.edu

 

Education and Training

  • Fellowship in Infectious Diseases, Baylor Affiliated Hospitals,  Houston TX, 1995-1997.
  • Residency in Internal Medicine, Baylor Affiliated Hospitals,  Houston TX, 1986-1989.
  • Ph. D., Department of Chemistry, Harvard University, Cambridge, MA, 1986
  • M. A., Department of Chemistry, Harvard University, Cambridge, MA, 1983
  • M. D.cum laude,Baylor College of Medicine, Houston, TX ,1980
  • B. A.sum. cum laude, Department of Chemistry, Trinity University, San Antonio, TX, 1977

Research Interests

Structural biology of infectious diseases, structure-aided drug design, protein crystallography, x-ray diffraction, structure and function of enzymes and proteins including antibiotic targets, redox proteins, nucleases, luciferase, and bacterial pathogenesis factors.

Recent Publications

Friedhoff, P., Franke, I., Meiss, G., Wende, W., Krause, K. L. and  Pingoud, A. "A similar active site for non-specific and specific endonucleases" (1999), Nature Struct. Biol., 6, 112-113.

Friedhoff, P., Franke, I., Krause, K. L. and  Pingoud, A., "Cleavage experiments with deoxythymidine 3'-5'-bis-(p-nitrophenyl phosphate) suggest that the homing endonuclease I-PpoI follows the same mechanism of phosphodiester bond hydrolysis as the non-specific Serratia nuclease" (1999), FEBS Letters, 443, 209-214.

Miller M.D., Cai J., and Krause, K. L., "The active site of Serratia endonuclease contains a conserved magnesium - water cluster" (1999), J. Mol. Biol., 288(5), 975-988.

Tanner, J. J., Tu, S-C, Barbour, L. J., Barnes, C. L., and Krause, K. L., "Unusual Folded Conformation of NAD+ Bound to Flavin Reductase P" Protein Science, (1999) Protein Sci. , 8, 1725-1732.

U. Strych, H. Huang, K. Krause, and M. Benedik, "Characterization  of the Alanine Racemases from Pseudomonas aeruginosa PAO1", (2000) Current Microbiology, 41: 290-294.

Krause, K. L. and Miller, M. D., "Using Electrostatics to Define the Active Site of Serratia Endonuclease" In Methods in Molecular Biology: Nuclease Methods and Protocols.  Eds. C. Schein, Humana Press, Totowa, NJ (2001), 160: 249-261.

Strych, U., Penland, R. L., Jimenez, M., Krause, K.L. and M.J. Benedik, "Characterization of the alanine racemases from two Mycobacteria" (2001) FEMS Microbiology Letters, 196: 93-98.

Musher, D. M., Dowell, M.E., Shortridge, V.D., Flamm, R.K., Jorgensen, J.H., Magueres, P. and K. L. Krause, "Emergence of macrolide resistance during treatment of pneumococcal pneumonia with azithromycin". (2002) New England J. Med., 346: 630-631.

Bussiere, D. and K. Krause, " Biotechnology and Drug Discovery: Two years into the new millennium", In Technical Proceedings of the Second International Conference on Computational Nanoscience and Nanotechnology, Matthew Laudon and Bart Romanowicz, eds. Computational Publications, Cambridge. MA. (2002) pp. 44-49.

Crossnoe, C. R., Germanas, J. P., LeMagueres, P., Mustata, G. and K. L. Krause, "The Crystal Structure of Trichomonas vaginalis Ferredoxin Provides Insight into Metronidazole Activation", (2002) J. Mol. Biol. (2002) 318:503-518.

Krause, Kurt L. and Miller, Mitchell D., " A new engine for cleaving nucleic acid", In Structures and Mechanisms: From Ashes to Enzymes, Gareth R. Eaton, Don C. Wiley, and Oleg Jardetzky, eds., ACS Symposium Series Volume 827, Oxford University Press, 2002 pp. 270-293.

Other Affiliations

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Last Change: 05May 1998