Mitchell D. Miller
Biographical Infromation
I grew up on the north side of Indianapolis, IN and graduated from
North Central High School in 1987. I then moved south to attend the
University of Houston, where I earned my B.S. in Biochemical and
Biophysical Sciences in 1991. Since I had recently joined the UH
Structural Biology group I decided to stay on as a graduate student
in the group. I recieved my Ph.D. in 1995 and am now looking for a post-doctoral
research position.
In my current research I am invloved in solving structures of biological
macromolecules using the techniques of x-ray crystallography. My thesis
advisor was Dr. Kurt L. Krause.
Projects
- Finding a lab for post-doctoral studies
- Setting up the UH Structural Biology WWW server
- Further structural studies with the Serratia marcescens
extracellular endonuclease - Including ultra high resolution
(>1.0 Å) refinement techniques.
Doctoral Dissertation
- Miller, M. D. (1995). Biochemical and Crystallographic Analysis of
the Extracellular Endonuclease from Serratia marcescens.
University of Houston.
Senior Honors Thesis
- Miller, M. D. (1991). Crystallization and preliminary
characterization of the extracellular nuclease from Serratia
marcescens. University of Houston.
Publications
- Miller, M.D., Cai, J., and Krause, K.L. (1999).
The active site of Serratia endonuclease contains a conserved
magnesium-water cluster. J. Mol. Biol. 288, 975-987.
- Tanner, J.J., Miller, M.D., Wilson, K.S., Tu, S-C, and
Krause, K.L. (1997).
Structure of bacterial luciferase beta-2 homodimer:
implications for flavin binding. Biochemistry 36, 665-672.
- Antosiewicz, J., Miller, M.D., Krause, K.L., and McCammon, J.A. (1997).
Simulation of electrostatic and hydrodynamic properties of
Serratia endonuclease. Biopolymers 41, 443-450.
- Plummer, B.F., Faiz, S., Wiederhold, T., Wooten, M., Agyin, J.K.,
Krause, K.L., Miller, M.D., and Watson, W.H. (1997).
Stereochemical pi-facial selectivity of the Diels-Alder reaction of
benz[a]aceanthrylene and 1,4-diphenylbenz[a]aceanthrylene.
J. Org. Chem. 62, 9290-9294.
- Miller, M.D., and Krause, K.L. (1996).
Identification of the Serratia endonuclease dimer: Structural basis
and implications for catalysis. Protein Science 5, 24-33.
- Subramanian, R. Kadish, K.M., Vijayashree, M.N., Gao, X., Jones, M.T.,
Miller, M.D., Krause, K.L., Suenobu, T., and Fukuzumi, S. (1996).
Chemical generation of C60^2- and electron transfer mechanism for the
reactions with alkyl bromides.
J. Phys. Chem. 100, 16327-16335.
- Miller, M.D., Tanner, J., Alpaugh, M., Benedik, M.J., and Krause,
K.L. (1994).
2.1 Å structure of Serratia endonuclease
suggests a mechanism for binding to double-stranded DNA.
Nature Struct. Biol. 1, 461-468.
- Miller, M. D., Benedik, M. J., Sullivan, M. C., Shipley, N. S., and
Krause, K.L. (1991).
Crystallization and preliminary crystallographic analysis of a novel
nuclease from Serratia marcescens.
J. Mol. Biol. 222, 27-30.
- Hecht, R.M., Garza, A., Lee, Y-H, Miller, M.D., and Pisegna, M.A.
(1989). Nucleotide sequence of the glyceraldehyde-3-phosphate
gene from Thermus aquaticus YT1. Nucl. Acids Res.,
17,10123.
Contact Information
Back to UH Structural Biology home page
Last Change: 22 January 1996 Mitch@bragg1.bchs.uh.edu